Product INN: Diclofenacum kalicum
Deva: 50 mg coated tabletes
Product ATC Code: M01AB05
Diseases for which treatment there is a need to decrease pain and inflammation. Acute musculoskeletal disorders: - pain, inflammation and swelling after an injury
Product Mechanism of Action
Diclofenac potassium has a pronounced anti-inflammatory and analgesic, and also antipyretic effects. A rapid effect of diclofenac potassium salt is suitable for the treatment of acute pain. Diclofenac potassium salt works on the prostaglandin biosynthesis inhibition, almost irreversibly inhibiting cyclo-oxygenase, key enzyme of arachidonic acid metabolism. Prostaglandins are mediators of inflammatory reactions (local capillary enlargement, edema, exudation) as sensitiser receptors for pain mediators (histamine, bradykinin), lowers the pain threshold, increases the hypothalamic thermoregulatory centre response to the pyrogenic effects that occur in the body in response to infectious agents and toxins effects. Diclofenac potassium salt calms moderate and severe pain. In post-traumatic and postoperative inflammatory cases, it quickly reduces both spontaneous pain and pain associated with movements and inflammation, as well as wound edema, effectively reduces the headache of migraine attacks and pain in case of dysmenorrhoea.
Product Therapeutic Indications
Diseases for which treatment there is a need to decrease pain and inflammation. Acute musculoskeletal disorders: - pain, inflammation and swelling after an injury (such as ligament strain); - pain, inflammation and swelling after surgery, dental or orthopedic surgery; - rheumatic diseases (rheumatoid arthritis, spondylarthritis, juvenile arthritis); - degenerative joint and spine diseases (arthrosis, spondiloze); - acutely painful and inflammatory conditions (such as periarthritis, bursitis, myositis, tendonitis, synovitis); - acute gout attack; - ear, nose and throat infections in the adjuvant therapy. Migraine; Dysmenorrhea.
A tablet is taken orally after meals with liquid.
Acute muscular-skeletal disorders:
Adults are indicated a dose of 50 mg 2-3 times a day. Treatment duration is usually several days.
Children over 14 years of age: a dose of 50-100 mg is used a day.
Medicine Dikloferol® 50 mg Coated Tablets coated tablets are not suitable to use for children younger than 14 years.
Migraine: therapy should be started as soon as the first symptoms of the disease occur. An initial dose is 50 mg. In case the ache does not disappear during 2 hours, a further dose of 50 mg may be used at intervals of 4-6 hours, not exceeding the total dose of 200 mg a day.
Dysmenorrhea: a dose is adjusted individually, usually 50-100 mg dose is used a day. If necessary, the dose may be increased till maximal dose of 150 mg a day (maximal period of therapy is 4 days).
Medicines unreasonable use is harmful to health.