Fenazepam

FENAZEPAM OLAINFARM

Product INN: Fenazepamum

Deva: 0.5 mg tablets; 1 mg tablets

Product ATC Code: N05BA

Product Description

Fenazepam is anxiolytic agent with an expressed anxiolytic, anticonvulsant, muscle relaxant, hypnotic, and sedative effect.

Product Mechanism of Action

Anxiolytic activity manifested as anxiety, fear, anxiety and emotional arousal reducing or inhibition; anticonvulsant activity – reducing frequency of epileptic seizures; myorelaxing action - skeletal muscles relaxation, sleep effect – sleep normalization, and the prolongation of sleep in case of insomnia caused by anxiety, sedative action – reducing the psychomotor agitation, while at the same time attenuation in concentration and reaction rate. Fenazepam can also be used to treat psychosis in a combination with antipsychotics.
The mechanism of action is not fully studied. It is considered that tranquilizers prevent subcortical centre (thalamus and the limbic system) agitation, as well as polysynaptic spinal reflexes that cause myorelaxation. Benzodiazepines implement their effects on subcortical centers by binding to specific benzodiazepine receptors, increasing gamma-amino-butyric acid (GABA) ergic processes and thereby producing a calming effect.
Fenazepam has therapeutic effect in case of chronic alcohol intoxication that expresses in the full or partial normalization of enzyme system activity changed because of the use of ethanol.

Product Therapeutic Indications

Treatment for anxiety, fear, psychomotor agitation, vegetative disorders and psychotic states; neuroses and neurosis-like states; psychopathy, and psychopathy-like conditions, insomnia, increased muscle tone, hyperkinesia, epilepsy, complex treatment  of alcohol abstinence syndrome.

Dosage

Fenazepam tablets are taken orally with liquid. It is recommended to use the lowest effective dose for the possible shortest time.

Anxiety, fear, psychomotor agitation, vegetative disorders, psychotic state: Adults are usually administered a single dose of 0.5 mg to 1 mg, the mean daily dose is 1.5 mg to 5 mg divided into 2-3 single doses (usually in the morning and the afternoon - 0.5 mg to 1 mg, at bedtime - up to 2.5 mg).
Neuroses and neurosis-like states, psychopathy, psychopathy-like conditions: Initial dose - 0.5 mg to 1 mg 2-3 times a day. If necessary, after 2-3 days the dose may be increased to 4-6 mg daily. In case of extreme agitation an initial dose is 3 mg a day, and then the dose is increased rapidly to reach the therapeutic effect.
The maximum daily dose should not exceed 10 mg.
Insomnia: 0.25 mg - 0.5 mg 20-30 minutes before bedtime.
Increased muscle tonus: 2-3 mg 1-2 times a day.
Epilepsy: 2-10 mg per day.
Alcohol abstinence syndrome complex treatment: 2.5-5 mg daily.
Elderly patients: daily dose is reduced 2-3 times.
Patients with hepatic and/or renal failure: the dose is reduced.
Children under the age of 18: Fenazepam Olainfarm must not be used.

Attachments

Before use, carefully read the instructions. Consult your doctor or pharmacist about the use of medicines.
Medicines unreasonable use is harmful to health.