Product INN: Omeprazolum
Deva: 20 mg Capsules
Product ATC Code: A02BC01
Omeprazols 20 mg Capsules is the first choice medicine in the treatment of the diseases that require gastric acid inhibition: duodenal ulcer; benign gastric ulcer; NSAID-associated duodenal or gastric ulcers and gastroduodenal erosions; duodenal ulcer associated with Helicobacter pylori; Helicobacter pylori eradication in combination with the appropriate antibacterial therapy; pathologic gastric hypersecretion in case of Zollinger-Ellison syndrome; gastric acid reduction during general anaesthesia; gastro-oesophageal reflux disease; acid reflux disease; acid related dyspepsia.
Product Mechanism of Action
Omeprazole inhibits gastric acid secretion. Omeprazole specifically blocks H+/K+- ATP enzyme system in the secretory surface of gastric parietal cells, blocks transport of hydrogen ions to stomach lumen and effectively inhibits both basal and stimulated gastric acid secretion. Omeprazole does not effect on receptors of acetylcholine and histamine. Omeprazole does not effect on evacuation of solid and liquid food from the stomach, inner factor secretion, and pepsin production.
Omeprazols 20 mg Capsules should be taken before meal. Capsules should be swallowed unbroken, with plenty of liquid. Patients, who have difficulty to swallow the whole capsule, may open capsule and mix its contents with small quantity of apple or orange juice and swallow the received quantity without chewing.
Benign gastric ulcer treatment: 20 mg once a day during 8 weeks. In severe or recurrent cases dose may be raised to 40 mg once a day. In case of recurrent ulcer in anamnesis, the patients are recommended to use 20 mg once daily.
Duodenal ulcer treatment: 20 mg once a day during 4 weeks. In severe or recurrent cases dose may be raised to 40 mg once a day. Maintenance for recurrent duodenal ulcer – 20 mg once daily.
Risk of recurrent ulcer often occurs:
- in patients with Helicobacter pylori infection,
- younger patients (< 60 years),
- in patients, who maintained symptoms longer than one year,
- in smokers.
NSAID-associated duodenal or gastric ulcers and gastroduodenal erosions: 20 mg once a day for 4 weeks, followed by further 4 weeks if necessary.
Prophylaxis of gastric or duodenal ulcers and gastroduodenal lesions in patients who had gastric or duodenal ulcers or gastroduodenal lesions caused by NSAID use – 20 mg of Omeprazols 20 mg Capsules once a day, proceeding to use these NSAID.
Helicobacter pylori (HP) eradication: basic scheme - 20 mg of Omeprazols 20 mg Capsules twice daily with clarithromycin 500 mg twice daily and with amoxicillin 1000 mg twice daily, course of treatment -7 days.
For eradication of Helicobacter pylori other 3-4 preparations combination are used also, one of which is Omeprazols 20 mg Capsules, others – antimicrobials.
Zollinger-Ellison syndrome: initial dose is 60 mg once daily, usually a dose is in the range of 20-120 mg daily. If a dose is higher than 80 mg, it is recommended to divide into two single doses.
Prophylaxis of acid aspiration during general anaesthesia: 40 mg on the preceding evening and further 40 mg in the morning 2-6 hours before surgery.
Gastro-oesophageal reflux disease (GEAS) including reflux oesophagitis:
the dose is 20 mg once daily during 4 weeks, if necessary the treatment continues for
4-8 weeks more. If the disease is not curable, the preparation is used at a dose of 40 mg once daily during 8 weeks; the drug can be used at a dose of 20 mg daily for a long term therapy.
Acid reflux disease: 20 mg once a day.
Acid related dyspepsia: 20 mg once a day during 2 - 4 weeks.
Children over two years in case of severe ulcerating reflux oesophagitis: 0.7-1.4 mg/kg of body weight daily for 4-12 weeks. Children with body weight 10-20 kg – the dose is 10 mg
daily, but with body weight over 20 kg – 20 mg daily. Maximal dose – 40 mg daily. The treatment is recommended to start in a hospital.
Recommended daily dose for patients with hepatic impairment should not exceed 20 mg.
Elderly patients – the dose should not be adjusted.
Patients with renal function impairment – the dose adjustment is not necessary.
Medicines unreasonable use is harmful to health.