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PAS-Na Olainfarm

Product INN: Natrii aminosalicylas dihydricus

Deva: 5.52 g powder for oral solutions

Product ATC Code: J04AA02

Product Description

p-Aminosalicylate sodium 5.52 g powder for oral solution is a synthetic second-line agent generally used in combined chemotherapy regiments for the treatment of tuberculosis. p-Aminosalicylate sodium salt has bacteriostatic activity against tuberculosis mycobacteria. In combination with other medicines p-Aminosalicylate sodium salt is used for the treatment of tuberculosis of different forms and localization.

Product Mechanism of Action

PAS-Na Olainfarm of 5.52 g powder is a second-line synthetic antituberculotic with bacteriostatic activity against Micobacterium tuberculosis. Competition of PAS with structural analogue para-aminobenzoic acid (PABA) at synthesis of folic acid, which is necessary for the process of growing and multiplication of Micobacterium tuberculosis, is the basis of bacteriostatic activity of the preparation. PAS replaces PABA in the process of synthesis of folic acid, as a result, normal synthesis of RNA, DNA and proteins of Micobacterium tuberculosis gets broken.
PAS-Na Olainfarm does not have effect on other microorganisms. To compete with PABA, PAS- sodium salt is necessary to use in high doses. PAS-sodium salt antituberculotic activity, as compared with the first-line preparations, is not so high, therefore, PAS-sodium salt is usually combined with other more effective antituberculotics. At monotherapy of the preparation Micobacterium tuberculosis rapidly develops resistance to PAS-sodium salt Olainfarm. In case of combined therapy mycobacteria drug resistance develops slower.

Dosage

PAS-Na Olainfarm powder is used only in combined chemotherapy regiments with other medicines for the treatment of tuberculosis.
The medicine should be taken after meals to diminish an irritating effect on stomach mucosa. Before administration the content of a sachet is dissolved by mixing in 100 ml of boiled water and the prepared solution should be used immediately.
The adults are administered in a dose of 8-12 g a day after meal. The daily dose is divided into 2-3 intakes.
The dose is decreased till 4-8 g per day for cachectic patients (with body weight less than 50 kg) and for those patients who have low tolerability of the preparation.
Children are administered in a dose of 200-300 mg/kg of body weight a day divided into 2-4 intakes. There is no information that administration safety of this medicine is restricted to any of children age group. Maximal dose is 12 g a day.
Patients with kidney insufficiency (creatinine clearance <30 ml/min) - a dose is 8 g a day, which is divided in 2 intakes.
Patients with liver insufficiency - there is no information about necessity to diminish a dose, though, characteristics of liver activity should be monitored during treatment period.
There is no information of PAS-Na use in elderly patients.

Attachments

Before use, carefully read the instructions. Consult your doctor or pharmacist about the use of medicines.
Medicines unreasonable use is harmful to health.